Type 2 Diabetes Management

Onglyza, A type 2 diabetes management drug has been proven effective

Posted on September 21, 2011 by Lu Young RN

In a year long study, Onglyza, a type 2 diabetes management drug has been proven effective when used in combination with insulin or metformin in keeping blood glucose levels lower in adult patients.  They showed that HgA1C was lowered nearly 3/4ths of 1% compared to a placebo.

According to PubMedHealth, “Saxagliptin (Onglyza) is used along with diet and exercise to lower blood sugar levels in patients with type 2 diabetes (condition in which blood sugar is too high because the body does not produce or use insulin normally). Saxagliptin is in a class of medications called dipeptidyl peptidase-4 (DPP-4) inhibitors. It works by increasing the amount of insulin produced by the body after meals when blood sugar is high.”

Results of an investigational Phase 3b clinical study, presented by Bristol-Myers Squibb Company and AstraZeneca at the 47th European Association for the Study of Diabetes (EASD), have shown that adding ONGLYZA (saxagliptin) 5 mg to ongoing insulin therapy (with or without metformin) maintained reductions of blood sugar levels (glycosylated hemoglobin levels, or HbA1c) in adult patients with type 2 diabetes.

In the 52-week analysis, which is an extension of a 24-week trial presented at the 71st American Diabetes Association (ADA) Scientific Sessions in San Diego, change from baseline in HbA1c in patients taking ONGLYZA 5 mg added to insulin (with or without metformin) was -0.75% compared to -0.38% for those taking placebo added to insulin (with or without metformin). There was also a greater increase from baseline mean daily insulin dose in patients who received placebo compared to patients who received ONGLYZA 5 mg (with or without metformin). It is unknown whether increased insulin doses by patients in the placebo group could have affected the magnitude of differences seen between the two treatment groups in the efficacy analyses.

Click here to view the original source of this post

Side effects between the study group using Onglyza, a type 2 diabetes management drug and the placebo were similar.  The most common side effects being bladder infections, low blood glucose (hypoglycemia), and head ache.

Make an appointment with your doctor, health care provider, or GP and ask if Onglyza, a type 2 diabetes management drug that has been proven effective can be added to your medication regimen.